diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index de6126d76..dde7c9183 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -35,12 +35,14 @@ jobs:
     with:
       coverage: 'codecov'
       posargs: '--color=yes'
+      toxdeps: tox-pypi-filter>=0.14
       envs: |
         - linux: py314
         - macos: py313
         - windows: py312
         - linux: py311
         - linux: py311-oldestdeps
+          toxdeps: tox-uv tox-pypi-filter>=0.14
     secrets:
       CODECOV_TOKEN: ${{ secrets.CODECOV_TOKEN }}
 
@@ -82,6 +84,7 @@ jobs:
     with:
       coverage: 'codecov'
       posargs: '--color=yes'
+      toxdeps: tox-pypi-filter>=0.14
       envs: |
         - linux: py312-online
         - linux: py313-devdeps
diff --git a/pyproject.toml b/pyproject.toml
index 117bc83e4..ab456adc0 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -24,7 +24,7 @@ dependencies = [
   # files with them unpinned so they are now required to read generated asdf
   # files.
   "asdf>=3.3.0",  # Required by gwcs 0.24
-  "asdf-astropy>=0.5.0",  # Required by gwcs 0.24
+  "asdf-astropy>=0.7.0",  # Required by gwcs 0.24
   "asdf-coordinates-schemas>=0.3.0",  # required by wcs-schemas 0.4
   "asdf-standard>=1.1.0",
   "asdf-transform-schemas>=0.6.0",
@@ -46,21 +46,21 @@ dynamic = ["version"]
 
 [project.optional-dependencies]
 tests = [
-  "pytest",
-  "pytest-asdf-plugin",
-  "pytest-doctestplus",
-  "pytest-cov",
-  "pytest-remotedata",
-  "pytest-mock",
-  "pytest-mpl",
-  "pytest-httpserver",
-  "pytest-filter-subpackage",
-  "pytest-benchmark",
-  "pytest-xdist",
-  "pytest-lazy-fixtures",
-  "hypothesis",
-  "tox",
-  "pydot",
+  "pytest>=8.0.1",
+  "pytest-asdf-plugin>=0.1.0",
+  "pytest-doctestplus>=1.4.0",
+  "pytest-cov>=6.0.0",
+  "pytest-remotedata>=0.4.0",
+  "pytest-mock>=3.13.0",
+  "pytest-mpl>=0.18.0",
+  "pytest-httpserver>=1.1.0",
+  "pytest-filter-subpackage>=0.2.0",
+  "pytest-benchmark>=5.0.0",
+  "pytest-xdist>=3.6.0",
+  "pytest-lazy-fixtures>=1.1.0",
+  "hypothesis>=6.84.0",
+  "tox>=4.0.0",
+  "pydot>=3.0.0",
 ]
 docs = [
   "sphinx<9",
@@ -183,3 +183,31 @@ version_file = "dkist/_version.py"
     directory = "performance"
     name = "Performance Improvements"
     showcontent = true
+
+[tool.uv]
+constraint-dependencies = [
+  # Core deps
+  "zarr>=2.15.0",
+  "pandas>=2.2.0",
+  "isodate>=0.6.0",
+  "fasteners>=0.18",
+  "lxml>=5.2.0",
+  "pyyaml>=6.0.2",
+  "cffi>=1.17.0",
+  "frozenlist>=1.5.0",
+  "pillow>=9.4.0",
+  "numcodecs>=0.11.0",
+  "pycparser>=2.22",
+  "asciitree>=0.3.3",
+  "entrypoints>=0.4",
+  "ply>=3.10",
+  "locket>=1.0.0",
+  "markupsafe>=3.0.2",
+  "jinja2>=3.1.3",
+  "defusedxml>=0.7.1",
+  "toolz>=1.0.0",
+  "urllib3>=2.2.0",
+  # test deps
+  "py-cpuinfo>=9.0.0",
+  "iniconfig>=2.3.0",
+]
diff --git a/pytest.ini b/pytest.ini
index f7895dee4..1a0aa1cb1 100644
--- a/pytest.ini
+++ b/pytest.ini
@@ -74,5 +74,5 @@ filterwarnings =
     ignore:pkg_resources is deprecated as an API.*:DeprecationWarning
     ignore:Deprecated call to .*pkg_resources\.declare_namespace.*mpl_toolkits.*:DeprecationWarning
     ignore:Signature b:UserWarning
-    ignore:Reshaping is producing a large chunk:dask.array.core.PerformanceWarning
+    # ignore:Reshaping is producing a large chunk:dask.array.core.PerformanceWarning
 	ignore:The chararray class is deprecated:DeprecationWarning
diff --git a/tox.ini b/tox.ini
index 39bd07189..a3ac08d6b 100644
--- a/tox.ini
+++ b/tox.ini
@@ -51,18 +51,23 @@ deps =
     devdeps: git+https://github.com/sunpy/mpl-animators
 	devdeps: git+https://github.com/globus/globus-sdk-python
     # Autogenerate oldest dependencies from info in setup.cfg
-    oldestdeps: minimum_dependencies
+    # oldestdeps: minimum_dependencies
     figure-!devdeps: matplotlib==3.10.8
     figure-!devdeps: mpl-animators==1.2.4
     figure-!devdeps: astropy==7.2.0
     figure-!devdeps: ndcube==2.4.0
+uv_resolution =
+    # The oldestdeps factor is intended to be used to install
+    # Let uv handle this for us by requesting all requirements should be
+    # resolved to their oldest compatible versions (including transitive dependencies)
+    oldestdeps: lowest
 # The following indicates which extras_require will be installed
 extras =
     tests
 commands_pre =
-    oldestdeps: minimum_dependencies dkist --filename requirements-min.txt
+    # oldestdeps: minimum_dependencies dkist --filename requirements-min.txt
     # We need to pin down the pyparsing transitive dependency because of matplotlib
-    oldestdeps: pip install -r requirements-min.txt pyparsing<3.3
+    # oldestdeps: pip install -r requirements-min.txt pyparsing<3.3
     pip freeze --all --no-input
 commands =
     figure: /bin/sh -c "mkdir -p ./figure_test_images; python -c 'import matplotlib as mpl; print(mpl.ft2font.__file__, mpl.ft2font.__freetype_version__, mpl.ft2font.__freetype_build_type__)' > ./figure_test_images/figure_version_info.txt"